Waters Xevo TQ S Micro Triple Quadrupole Mass Spectrometer with Acquity I-Class UPLC Front End

Insights by AMPTIUS | AMP Tech Instruments

Ultra-Sensitive LC-MS/MS for Quantitative Analysis

If your laboratory is struggling to hit lower limits of quantification or manage complex sample backgrounds, the Waters Xevo TQ-S micro LC-MS/MS system delivers extreme sensitivity and high-throughput speed in a remarkably compact footprint. Powered by StepWave ion transfer technology and rapid polarity switching, this advanced triple quadrupole mass spectrometer maximizes ion transmission while stripping away neutral contamination to achieve exceptional signal-to-noise performance during intense multiple reaction monitoring (MRM) workflows. The integrated ACQUITY UPLC I-Class front-end features ultra-low dispersion fluidics operating flawlessly at pressures up to 18,000 psi (1,240 bar), generating razor-sharp peak widths and drastically shortening analytical run times. It is a premier, robust powerhouse for high-throughput environmental labs measuring emerging contaminants like PFAS, as well as pharmaceutical and biotechnology facilities running demanding bioanalysis, pharmacokinetic studies, and trace impurity profiling.

ACQUITY UPLC I-Class Xevo TQ-S Micro System Price and Cost of Ownership: Reliable Performance at Lower Cost

Certified refurbished systems typically range from approximately $100,000 to $125,000, offering substantial savings compared to new systems, which commonly range from approximately $300,000 to $365,000 depending on configuration, software packages, and application-specific options. Beyond the initial acquisition cost, laboratories should budget for ongoing operational expenses, including UPLC columns, solvents, calibration standards, sample preparation supplies, nitrogen gas generation or supply, pump seals, autosampler consumables, ion source maintenance, vacuum pump servicing, replacement ion optics, software support, preventive maintenance, and compliance-related qualification services. Long-term ownership considerations may also include detector maintenance, performance verification, service agreements, and routine system optimization to ensure consistent analytical performance and regulatory compliance. Purchasing a certified refurbished Waters Xevo TQ-S Micro Triple Quadrupole LC-MS/MS with ACQUITY I-Class Front End allows laboratories to significantly reduce capital expenditures while maintaining access to exceptional MRM sensitivity, robust quantitative accuracy, high-throughput UPLC separations, and proven analytical performance for applications such as PFAS testing, pesticide residue analysis, pharmaceutical bioanalysis, mycotoxin screening, environmental monitoring, food safety compliance, and targeted contaminant quantification.

EPA Method 1633: Analysis of Per- and Polyfluoroalkyl Substances (PFAS) Using the Waters Xevo TQ-S Micro System LC/MS/MS with Acquity I-Class UPLC Front End

The Waters Xevo TQ-S Micro Triple Quadrupole Mass Spectrometer with an Waters ACQUITY UPLC I-Class System front end provides a highly effective platform for EPA Method 1633, which is used for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental matrices including wastewater, surface water, groundwater, soil, sediment, biosolids, and tissue samples. The ACQUITY I-Class UPLC delivers exceptional chromatographic resolution, precise solvent delivery, and high-throughput separations that are critical for resolving complex PFAS analyte panels. The Xevo TQ-S Micro offers outstanding sensitivity and selectivity through Multiple Reaction Monitoring (MRM), enabling accurate quantitation of target PFAS compounds at trace and ultra-trace concentration levels while minimizing matrix interferences. Environmental laboratories benefit from robust isotope dilution quantitation, broad dynamic range, excellent reproducibility, and reliable detection of both legacy and emerging PFAS compounds across challenging sample matrices. The system's high sensitivity supports stringent reporting requirements and data quality objectives associated with modern PFAS monitoring programs, remediation projects, and regulatory compliance initiatives. Combined with advanced UPLC performance, highly sensitive triple quadrupole mass spectrometry, and proven Waters reliability, the Waters Xevo TQ-S Micro LC-MS/MS with ACQUITY I-Class Front End provides a powerful solution for EPA Method 1633 PFAS analysis and environmental contaminant monitoring applications.

AMP Tech Analytical Solutions for Academic Research and Grant-Funded Laboratories

At AMPTIUS | AMP Tech Instruments, we support the advancement of scientific education and innovation by providing cost-effective analytical instruments tailored to the unique budget constraints of the academic sector. Every pre-owned system in our inventory is independently evaluated and fully verified within our in-house testing laboratory, making our AMP Tech Certified equipment an ideal choice for university chemistry departments, core facilities, and researchers optimizing limited grant funding. Because academic applications vary heavily from undergraduate teaching labs to complex graduate research, we precisely document each unique listing to ensure the specific components align with your educational goals or specific institutional SOPs. To guarantee that your system includes the exact module configuration required for your research methodology and to align with your university’s procurement process or funding timeline, we highly encourage you to connect directly with our active sales management team or request a customized quote before purchase.