Agilent 6490 Triple Quadrupole LC-MS/MS System with 1200 1260 Infinity Front-End

Insights by AMPTIUS | AMP Tech Instruments

Ultra-Sensitive Quantitative Mass Spectrometry Across Key Industries

If your laboratory is struggling to hit ultra-low detection limits or clear complex sample backlogs, the Agilent 6490 Triple Quadrupole LC-MS/MS system delivers the elite sensitivity and speed required for trace-level quantification. Driven by innovative iFunnel technology and hexabore capillary ion optics, this high-performance mass spectrometer maximizes ion transmission while stripping away chemical noise to achieve an incredible six orders of linear dynamic range and sub-picogram detection limits. The integrated Agilent Jet Stream (AJS) electrospray ionization source focuses the ion beam for enhanced signal response, working seamlessly with high-speed Multiple Reaction Monitoring (MRM) to handle multiplexed sequences without compromising reproducibility. It is a premier, robust powerhouse for high-throughput environmental labs measuring emerging contaminants like PFAS, as well as pharmaceutical and clinical research facilities running demanding bioanalysis, drug metabolism, and pharmacokinetic studies.

Agilent 6490 1200 1260 Triple Quad LC MS Price and Cost of Ownership: Reliable Performance at Lower Cost

Certified refurbished systems typically range from approximately $110,000 to $125,000, providing significant cost savings compared to current-generation platforms such as the Agilent 6475 or 6495 Triple Quadrupole LC-MS/MS systems paired with a 1260 Infinity II LC, which commonly range from approximately $340,000 to $410,000 or more depending on configuration, software, and application-specific options. In addition to the initial acquisition cost, laboratories should budget for ongoing operational expenses, including LC columns, solvents, calibration standards, sample preparation supplies, pump seals, check valves, autosampler consumables, nitrogen gas generation or supply, roughing pump maintenance, source cleaning, capillary and ion optics replacement, software support, preventive maintenance, and compliance-related qualification services. Long-term ownership considerations may also include vacuum system servicing, detector maintenance, performance verification, and service agreements designed to maximize uptime and analytical reliability. Purchasing a certified refurbished Agilent 6490 LC-MS/MS System with a 1260/1200 Infinity front-end enables laboratories to dramatically reduce capital expenditures while maintaining access to high-sensitivity Multiple Reaction Monitoring (MRM), robust quantitative performance, dependable chromatographic separations, and proven analytical capabilities for applications such as PFAS testing, pesticide residue analysis, pharmaceutical bioanalysis, mycotoxin screening, environmental monitoring, and targeted contaminant quantification.

EPA Method 1633A: Analysis of Per- and Polyfluoroalkyl Substances (PFAS) Using the Agilent 6490 Triple Quadrupole LC/MS/MS with 1200 1260 Infinity HPLC System

The Agilent 6490 Triple Quadrupole LC-MS/MS System with an Agilent 1260/1200 Infinity front-end is exceptionally well-suited for EPA Method 1633A, providing the sensitivity, selectivity, and quantitative accuracy required for the analysis of per- and polyfluoroalkyl substances (PFAS) in aqueous, solid, biosolid, sediment, and tissue matrices. The triple quadrupole mass spectrometer utilizes Multiple Reaction Monitoring (MRM) to deliver highly selective detection and reliable quantitation of target PFAS compounds at trace and ultra-trace concentrations, helping laboratories meet the stringent performance requirements associated with modern environmental monitoring programs. The Agilent 1260/1200 Infinity LC front-end provides stable flow control, reproducible chromatographic separations, and dependable retention time performance, which are critical for analyzing complex sample matrices and large PFAS target lists. Environmental laboratories benefit from excellent sensitivity, broad dynamic range, robust isotope dilution quantitation workflows, and high sample throughput capabilities that support regulatory compliance and data quality objectives. Combined with proven Agilent reliability, advanced quantitative performance, and strong compatibility with EPA Method 1633A workflows, the Agilent 6490 LC-MS/MS System provides a powerful solution for PFAS investigations, environmental remediation projects, wastewater monitoring, biosolids testing, and comprehensive contaminant assessment programs.

AMP Tech Analytical Solutions for Academic Research and Grant-Funded Laboratories

At AMPTIUS | AMP Tech Instruments, we support the advancement of scientific education and innovation by providing cost-effective analytical instruments tailored to the unique budget constraints of the academic sector. Every pre-owned system in our inventory is independently evaluated and fully verified within our in-house testing laboratory, making our AMP Tech Certified equipment an ideal choice for university chemistry departments, core facilities, and researchers optimizing limited grant funding. Because academic applications vary heavily from undergraduate teaching labs to complex graduate research, we precisely document each unique listing to ensure the specific components align with your educational goals or specific institutional SOPs. To guarantee that your system includes the exact module configuration required for your research methodology and to align with your university’s procurement process or funding timeline, we highly encourage you to connect directly with our active sales management team or request a customized quote before purchase.