Agilent 6490 Triple Quadrupole LC-MS/MS Mass Spectrometer System

Insights by AMPTIUS | AMP Tech Instruments

Ultra-Sensitive Quantitative Analysis Across Key Industries

If your laboratory is struggling to hit ultra-low detection limits or manage dense sample matrices, the Agilent 6490 Triple Quadrupole LC-MS/MS mass spectrometer delivers the elite sensitivity and speed required for trace-level quantification. Engineered with innovative iFunnel technology and hexabore capillary ion optics, this high-performance mass analyzer maximizes ion transmission while stripping away chemical noise to achieve an incredible six orders of linear dynamic range and sub-picogram detection limits. Designed to integrate seamlessly with your existing Agilent 1200, 1260 Infinity, or 1290 Infinity LC front-end systems, the platform utilizes an Agilent Jet Stream (AJS) electrospray ionization source alongside high-speed Multiple Reaction Monitoring (MRM) to handle complex multiplexed sequences with outstanding reproducibility. It is a premier, robust powerhouse for high-throughput environmental labs measuring emerging contaminants like PFAS, as well as pharmaceutical and clinical research facilities running demanding bioanalysis, drug metabolism, and pharmacokinetic studies.

Agilent 6490 LC-MS/MS Price and Cost of Ownership: Reliable Performance at Lower Cost

Certified refurbished systems typically range from approximately $69,000 to $125,000, providing substantial capital savings compared to current-generation platforms such as the Agilent 6475 Triple Quadrupole LC-MS/MS System, which commonly range from approximately $220,000 to $300,000 depending on configuration, software, and application-specific options. Beyond the initial acquisition cost, laboratories should budget for ongoing operational expenses, including LC columns, solvents, calibration standards, sample preparation supplies, nitrogen gas generation or supply, vacuum pump maintenance, ion source cleaning, capillary and ion optics replacement, software licensing, preventive maintenance, and compliance-related qualification services. Long-term ownership considerations may also include detector servicing, vacuum system upkeep, performance verification, and optional service agreements designed to maximize instrument uptime and analytical reliability. Purchasing a certified refurbished Agilent 6490 Triple Quadrupole LC-MS/MS System allows laboratories to significantly reduce capital expenditures while maintaining access to exceptional Multiple Reaction Monitoring (MRM) sensitivity, trace-level quantitation capabilities, broad dynamic range, and proven analytical performance for applications such as PFAS testing, pesticide residue analysis, pharmaceutical bioanalysis, mycotoxin screening, environmental monitoring, and targeted contaminant quantification.

EPA Method 537.1, 533, and 1633 Using the Agilent 6490 Triple Quad LC MS MS System

The Agilent 6490 Triple Quadrupole LC-MS/MS System is exceptionally well-suited for PFAS analysis workflows associated with EPA Methods 537.1, 533, and 1633, providing the ultra-trace sensitivity, selectivity, and quantitative accuracy required for the determination of per- and polyfluoroalkyl substances in drinking water, wastewater, groundwater, surface water, biosolids, soils, sediments, tissues, and other environmental matrices. Utilizing advanced Multiple Reaction Monitoring (MRM), the 6490 delivers highly selective detection and reliable quantitation of both legacy and emerging PFAS compounds at low parts-per-trillion (ppt) concentrations while minimizing matrix interferences. Its broad dynamic range and robust isotope dilution quantitation capabilities support the stringent quality control and reporting requirements specified by these EPA methods. Environmental laboratories benefit from excellent reproducibility, high sample throughput, and dependable performance across complex sample types, enabling efficient compliance monitoring, remediation studies, source investigations, and environmental risk assessments. Combined with proven Agilent reliability, exceptional quantitative performance, and strong compatibility with modern PFAS workflows, the Agilent 6490 Triple Quadrupole LC-MS/MS System provides a powerful analytical solution for laboratories conducting EPA 537.1, EPA 533, and EPA 1633 PFAS testing programs.

AMP Tech Analytical Solutions for Academic Research and Grant-Funded Laboratories

At AMPTIUS | AMP Tech Instruments, we support the advancement of scientific education and innovation by providing cost-effective analytical instruments tailored to the unique budget constraints of the academic sector. Every pre-owned system in our inventory is independently evaluated and fully verified within our in-house testing laboratory, making our AMP Tech Certified equipment an ideal choice for university chemistry departments, core facilities, and researchers optimizing limited grant funding. Because academic applications vary heavily from undergraduate teaching labs to complex graduate research, we precisely document each unique listing to ensure the specific components align with your educational goals or specific institutional SOPs. To guarantee that your system includes the exact module configuration required for your research methodology and to align with your university’s procurement process or funding timeline, we highly encourage you to connect directly with our active sales management team or request a customized quote before purchase.