Agilent 6490 Triple Quadrupole LC-MS/MS System with 1260 Infinity II DAD Front-End

Insights by AMPTIUS | AMP Tech Instruments

Price and cost of ownership of Agilent 6490 Triple Quadrupole LC-MS/MS

Investing in an Agilent 6490 Triple Quadrupole LC-MS/MS system requires balancing upfront cost with long-term operational expenses. A new system typically costs around $322,000, while a certified refurbished unit averages approximately $110,000, offering substantial capital savings without compromising core performance. In addition to the purchase price, laboratories should account for ongoing costs such as columns, solvents, ion source components, calibration standards, and routine maintenance to ensure consistent analytical accuracy. Software licensing, updates, and compliance-related expenses may also apply, particularly in regulated environments such as pharmaceutical, clinical, and environmental laboratories. Certified refurbished systems undergo thorough testing, requalification, and often include warranty coverage, making them a practical and cost-effective option for labs seeking high-end LC-MS/MS capabilities while maintaining long-term financial efficiency.

Labs & Universities Utilizing the Agilent 6490 LC-MS/MS for Advanced Research

The Agilent 6490 Triple Quadrupole LC-MS/MS with 1260 Infinity II DAD Front-End is widely recognized for its role in advanced academic and research applications. At the University of Colorado Anschutz Medical Campus, the School of Pharmacy’s Mass Spectrometry Facility utilizes this platform for proteomics, metabolomics, and small molecule analysis, highlighting its versatility and high-performance capabilities. Similarly, researchers at the University of Victoria’s Proteomics Centre have developed multiplexed MRM assays using the Agilent 6490 to quantify dozens of cardiovascular disease biomarkers in human plasma, demonstrating its strength in targeted quantitative workflows. With exceptional sensitivity, robust MRM performance, and integrated chromatographic and spectral capabilities, this configuration remains a trusted solution for laboratories conducting cutting-edge analytical research.