Thermo Scientific TSQ Quantis Triple Quadrupole MS with Vanquish UHPLC

Insights by AMPTIUS | AMP Tech Instruments

Ultra-Sensitive Quantitative LC-MS/MS for Regulated Analytical Laboratories

If your laboratory is struggling to hit lower limits of quantification or manage complex sample matrices, the Thermo Scientific TSQ Quantis LC-MS/MS system delivers the extreme sensitivity and speed your workflow demands. By pairing the ultra-high-pressure performance of the Vanquish UHPLC with an advanced triple quadrupole mass analyzer, this platform utilizes OptaMax NG ion source with HESI probe and rapid selected reaction monitoring (SRM) to reliably detect trace-level target compounds across six orders of linear dynamic range. The system features a wide mass range of m/z 5 to 3,000 and ultra-fast polarity switching, ensuring you capture maximum data per run without losing quantitative accuracy or retention time reproducibility. It is a premium, robust setup for high-throughput environmental labs analyzing emerging contaminants like PFAS, as well as regulated pharmaceutical facilities running demanding bioanalysis, pharmacokinetic studies, and impurity profiling workflows.

LC MS MS Price and Cost of Ownership: Reliable Performance at Lower Cost

The Thermo Scientific TSQ Quantis LC-MS/MS with Thermo Scientific Vanquish UHPLC represents a significant investment for laboratories requiring highly sensitive and reproducible quantitative LC-MS/MS analysis in pharmaceutical, environmental, food safety, clinical, and toxicology applications. New systems typically range from $300,000 to $450,000 depending on detector configuration, ion source options, software packages, and UHPLC modules, while third-party refurbished systems generally range from $85,000 to $160,000, offering substantial capital savings without sacrificing analytical performance. In addition to the initial purchase cost, laboratories should consider ongoing operational expenses such as high-purity nitrogen gas generation or supply, LC solvents, mobile phase additives, sample preparation consumables, analytical columns, calibration standards, ion source maintenance, vacuum pump servicing, software licensing, preventive maintenance, replacement parts, and compliance-related qualification support for FDA, EPA, ISO, USP, AOAC, and cGMP workflows. Long-term ownership considerations may also include service contracts, detector optimization, mass calibration, system validation, and maintaining chromatographic performance for high-throughput analytical environments. Purchasing a professionally refurbished TSQ Quantis LC-MS/MS with Vanquish UHPLC allows laboratories to achieve reliable triple quadrupole mass spectrometry performance, excellent chromatographic reproducibility, and dependable long-term operation while significantly reducing acquisition costs and maximizing overall laboratory value.

EPA Method 533: Determination of Per- and Polyfluoroalkyl Substances Using the TSQ Quantis Triple Quad MS with Vanquish UHPLC

The Thermo Scientific TSQ Quantis LC-MS/MS with Thermo Scientific Vanquish UHPLC System provides a highly sensitive and reliable analytical platform for laboratories performing EPA Method 533 for the determination of per- and polyfluoroalkyl substances (PFAS) in drinking water. This configuration combines fast and reproducible UHPLC separation with highly selective triple quadrupole mass spectrometry to support accurate trace-level quantitation. EPA Method 533 covers 25 PFAS analytes, with particular emphasis on short-chain compounds not addressed by Method 537.1, making this system well-suited for comprehensive PFAS compliance testing. The Vanquish UHPLC delivers stable gradient performance, low carryover, and precise retention time reproducibility, while the TSQ Quantis LC-MS/MS utilizes advanced Multiple Reaction Monitoring (MRM) capabilities for exceptional sensitivity, selectivity, and low detection limits required for regulated PFAS analysis. The system is well suited for high-throughput environmental laboratories requiring dependable analytical reproducibility, strong matrix tolerance, and reliable quantitation across challenging water samples. Combined with rapid polarity switching, automated workflow compatibility, and robust long-term performance, the Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC provides laboratories with excellent analytical confidence and operational reliability for EPA Method 533 PFAS testing applications.

AMP Tech Analytical Solutions for Academic Research and Grant-Funded Laboratories

At AMPTIUS | AMP Tech Instruments, we support the advancement of scientific education and innovation by providing cost-effective analytical instruments tailored to the unique budget constraints of the academic sector. Every pre-owned system in our inventory is independently evaluated and fully verified within our in-house testing laboratory, making our AMP Tech Certified equipment an ideal choice for university chemistry departments, core facilities, and researchers optimizing limited grant funding. Because academic applications vary heavily from undergraduate teaching labs to complex graduate research, we precisely document each unique listing to ensure the specific components align with your educational goals or specific institutional SOPs. To guarantee that your system includes the exact module configuration required for your research methodology and to align with your university’s procurement process or funding timeline, we highly encourage you to connect directly with our active sales management team or request a customized quote before purchase.