Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC

Insights by AMPTIUS | AMP Tech Instruments

Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC Applications in Pharma, Food, and Environmental Labs

The Thermo Scientific TSQ Quantis LC-MS/MS with Thermo Scientific Vanquish UHPLC is widely used for high-sensitivity quantitative analysis across environmental, pharmaceutical, food safety, clinical, forensic, and industrial laboratories. Common applications include PFAS analysis under EPA Methods 533 and 537.1, pesticide residue testing in food and agricultural products, pharmaceutical impurity profiling, therapeutic drug monitoring, clinical research, toxicology screening, veterinary drug residue analysis, biomarker quantitation, metabolomics workflows, and emerging contaminant monitoring in environmental samples. The system is also commonly utilized for mycotoxin analysis, endocrine disruptor detection, cannabis potency and contaminant testing, residual antibiotic analysis, and chemical exposure studies requiring trace-level sensitivity and high analytical selectivity. Its triple quadrupole MRM capabilities, combined with the fast and precise chromatographic performance of the Vanquish UHPLC, make the platform especially valuable for laboratories requiring accurate quantitation, high sample throughput, and reliable reproducibility in regulated EPA, FDA, ISO, and cGMP environments.

Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC: Refurbished System Benefits and Pricing

The Thermo Scientific TSQ Quantis LC-MS/MS with Thermo Scientific Vanquish UHPLC represents a significant investment for laboratories requiring highly sensitive and reproducible quantitative LC-MS/MS analysis in pharmaceutical, environmental, food safety, clinical, and toxicology applications. New systems typically range from $300,000 to $450,000 depending on detector configuration, ion source options, software packages, and UHPLC modules, while certified refurbished systems generally range from $90,000 to $160,000, offering substantial capital savings without sacrificing analytical performance. In addition to the initial purchase cost, laboratories should consider ongoing operational expenses such as high-purity nitrogen gas generation or supply, LC solvents, mobile phase additives, sample preparation consumables, analytical columns, calibration standards, ion source maintenance, vacuum pump servicing, software licensing, preventive maintenance, replacement parts, and compliance-related qualification support for FDA, EPA, ISO, USP, AOAC, and cGMP workflows. Long-term ownership considerations may also include service contracts, detector optimization, mass calibration, system validation, and maintaining chromatographic performance for high-throughput analytical environments. Purchasing a certified refurbished TSQ Quantis LC-MS/MS with Vanquish UHPLC allows laboratories to achieve reliable triple quadrupole mass spectrometry performance, excellent chromatographic reproducibility, and dependable long-term operation while significantly reducing acquisition costs and maximizing overall laboratory value.

EPA Method 533: Determination of Per- and Polyfluoroalkyl Substances Using Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC

The Thermo Scientific TSQ Quantis LC-MS/MS with Thermo Scientific Vanquish UHPLC System provides a highly sensitive and reliable analytical platform for laboratories performing EPA Method 533 for the determination of per- and polyfluoroalkyl substances (PFAS) in drinking water. This configuration combines fast and reproducible UHPLC separation with highly selective triple quadrupole mass spectrometry to support accurate trace-level quantitation of short-chain PFAS compounds and other emerging contaminants in complex environmental matrices. The Vanquish UHPLC delivers stable gradient performance, low carryover, and precise retention time reproducibility, while the TSQ Quantis LC-MS/MS utilizes advanced Multiple Reaction Monitoring (MRM) capabilities for exceptional sensitivity, selectivity, and low detection limits required for regulated PFAS analysis. The system is well suited for high-throughput environmental laboratories requiring dependable analytical reproducibility, strong matrix tolerance, and reliable quantitation across challenging water samples. Combined with rapid polarity switching, automated workflow compatibility, and robust long-term performance, the Thermo Scientific TSQ Quantis LC-MS/MS with Vanquish UHPLC provides laboratories with excellent analytical confidence and operational reliability for EPA Method 533 PFAS testing applications.