Waters ACQUITY UPLC H Class with PDA Detector, FTN, and Quaternary Solvent Manager

Insights by AMPTIUS | AMP Tech Instruments

High-Resolution Chromatography with Maximum Method Flexibility

When your laboratory needs to streamline complex method development without sacrificing high-pressure performance, the Waters ACQUITY UPLC H-Class system provides the ultimate flexibility for your analytical workflow. Equipped with a Quaternary Solvent Manager (QSM) that handles pressures up to 15,000 psi (1,034 bar), this multi-solvent blending platform allows for the seamless replication and transfer of traditional HPLC methods directly into high-resolution UPLC speeds. The advanced Photodiode Array (PDA) Detector delivers full-spectrum UV-Vis acquisition from 190–500 nm for simultaneous multi-wavelength monitoring and precise peak purity analysis, while the Flow-Through Needle (FTN) Sample Manager minimizes carryover and maximizes injection precision during high-throughput, unattended runs. It is an ideal, robust system for pharmaceutical labs running complex stability studies, environmental operations mapping pesticide residues, and industrial chemical facilities demanding rapid, reproducible QA/QC analysis.

Waters ACQUITY UPLC Price and Cost of Ownership: Reliable Performance at Lower Cost

The Waters ACQUITY UPLC H-Class System with Photodiode Array (PDA) Detector, Flow-Through Needle (FTN) Sample Manager, and Quaternary Solvent Manager (QSM) provides a versatile and high-performance ultra-high-performance liquid chromatography solution for pharmaceutical, environmental, food safety, biotechnology, and research laboratories. New systems typically range from approximately $75,000 to $130,000, depending on detector configuration, automation features, software packages, and compliance options, while certified refurbished systems generally range from $16,000 to $28,000, offering substantial savings on initial capital investment. In addition to acquisition costs, laboratories should consider ongoing operational expenses such as UPLC solvents, mobile phase additives, high-pressure analytical columns, PDA lamp replacements, pump seals, tubing, autosampler consumables, calibration standards, preventive maintenance, software licensing, and compliance-related qualification support for USP, FDA, ICH, EPA, AOAC, ISO, and cGMP workflows. Long-term ownership considerations may also include PDA detector servicing, FTN Sample Manager maintenance, Quaternary Solvent Manager servicing, replacement electronic components, and optional service contracts to maintain stable ultra-high-pressure operation and dependable chromatographic reproducibility in high-throughput laboratory environments. Purchasing a certified refurbished Waters ACQUITY UPLC H-Class System with PDA Detector, FTN, and Quaternary SM allows laboratories to significantly reduce ownership costs while still benefiting from fast separations, full spectral acquisition, flexible solvent blending, low carryover, and proven long-term analytical performance for regulated and research-based applications.

EPA Method 555: Using the Waters ACQUITY UPLC H Class with PDA Detector

The Waters ACQUITY UPLC H-Class System with Photodiode Array (PDA) Detector, Flow-Through Needle (FTN) Sample Manager, and Quaternary Solvent Manager (QSM) provides a highly effective and regulation-aligned platform for laboratories performing EPA Method 555 for the determination of chlorinated acids in drinking water and environmental samples. This UPLC configuration delivers fast and reproducible chromatographic separations with excellent resolution for chlorinated herbicides and acidic organic compounds commonly analyzed in regulated water testing workflows. The PDA Detector supports full spectral acquisition and multi-wavelength analysis, which is critical for compound confirmation and peak purity evaluation required by EPA Method 555, while the Quaternary Solvent Manager enables flexible mobile phase blending and stable gradient performance for optimized separations. The FTN Sample Manager minimizes carryover and improves injection reproducibility, supporting consistent quantitative accuracy in high-throughput laboratory environments. Combined with low solvent consumption, stable retention time performance, automated workflow compatibility, and dependable long-term chromatographic reproducibility, the Waters ACQUITY UPLC H-Class System with PDA Detector, FTN, and Quaternary SM provides laboratories with excellent analytical confidence and operational efficiency for EPA Method 555 chlorinated acid analysis applications.

AMP Tech Analytical Solutions for Academic Research and Grant-Funded Laboratories

At AMPTIUS | AMP Tech Instruments, we support the advancement of scientific education and innovation by providing cost-effective analytical instruments tailored to the unique budget constraints of the academic sector. Every pre-owned system in our inventory is independently evaluated and fully verified within our in-house testing laboratory, making our AMP Tech Certified equipment an ideal choice for university chemistry departments, core facilities, and researchers optimizing limited grant funding. Because academic applications vary heavily from undergraduate teaching labs to complex graduate research, we precisely document each unique listing to ensure the specific components align with your educational goals or specific institutional SOPs. To guarantee that your system includes the exact module configuration required for your research methodology and to align with your university’s procurement process or funding timeline, we highly encourage you to connect directly with our active sales management team or request a customized quote before purchase.